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What is
Huntington's Disease?
Huntington’s Disease (HD) is a rare, hereditary brain disorder that causes nerve cells in the brain to break down over time. It affects both the mind and body, gradually deteriorating a person’s ability to move, think, speak, and function independently.
Often described as having Parkinson’s, ALS, and Alzheimer’s all at once, HD is a progressive, terminal condition that currently has no cure.
🧬 The Genetic Cause
HD is caused by a mutation in the HTT gene, where an abnormal repetition of the CAG sequence creates a faulty protein. Every person has this gene — but if you inherit 39 or more CAG repeats, you will develop Huntington’s Disease at some point in your life.
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Onset usually occurs between the ages of 30 and 50
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Each child of a parent with HD has a 50% chance of inheriting the gene
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A simple genetic test can confirm a diagnosis
🧠 Common Symptons
HD affects everyone differently, but symptoms may include:
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Involuntary movements (chorea or tremors)
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Impaired balance and coordination
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Slurred speech and difficulty swallowing
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Memory loss, confusion, and impaired judgment
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Mood changes such as depression, anxiety, or OCD
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Weight loss and muscle deterioration
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Changes in behavior or personality
As the disease progresses, daily tasks become increasingly difficult — often requiring full-time care.
📊 How Many Are Affected?
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Approximately 41,000 Americans are living with Huntington’s Disease today
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An estimated 200,000 more are considered "at-risk" of inheriting the gene
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HD does not discriminate — it affects all genders, ethnicities, and backgrounds
✨ Juvenile HD, a rarer and more aggressive form of the disease that affects children and teens, is explored [here ➝](link to your JHD page)
📚 A Brief History of HD
HD was first described in 1872 by American physician Dr. George Huntington in a paper titled “On Chorea.” His description of the disease — including its hereditary nature — was groundbreaking.
In 1993, researchers discovered the HTT gene mutation, allowing for predictive genetic testing. Since then, research has continued to accelerate in search of treatments and, ultimately, a cure.
One of the most well-known individuals affected by HD was folk singer Woody Guthrie, who passed away in 1967 from HD-related complications. His legacy continues to raise awareness for generations.
💡 Want to Learn More?
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HDSA.org – Huntington’s Disease Society of America
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HelpCureHD.org – Focused on fertility assistance and education
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HDYO.org – Youth-focused resources and support
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HDBuzz.net – High-quality HD research news to the global HD community
💙 We're Here For You
If you or someone you love is impacted by Huntington’s Disease, you are not alone.
Champions for HD exists to support families — with compassion, resources, and hope.